Cell biology

The Investigation/Study/Assay (ISA) tab-delimited (TAB) format is a general purpose framework with which to collect and communicate complex metadata (i.e. sample characteristics, technologies used, type of measurements made) from 'omics-based' experiments employing a combination of technologies.

Created by core developers from the University of Oxford, ISA-TAB v1.0 was released in November 2008.

The MIBBI Project was an international collaboration seeking to harmonize the efforts of the various bioscience communities developing Minimum Information (MI) reporting guidelines or checklists. Approximately 40 such checklists registered with the project.

The MIBBI Foundry was an attempt to identify common features of the various MI checklists and codify them into modules. The aim was to evolve the existing checklists towards formal intercompatibility, and to enable new checklists to be produced by selecting and extending the available modules.

The concept was realized initially through the joint efforts of the Proteomics Standards Initiative, the Genomic Standards Consortium and the MGED RSBI Working Groups.

While the MIBBI Foundry did not develop to the point where it could become a true, technical parent standard for the MI checklists, the MIBBI Project provided a useful grouping of standards that shared a common purpose, philosophy and inspiration.

MIxS is a superset of metadata elements that can be used to compile minimum information checklists for reporting sequencing data. It was developed by the Genomic Standards Consortium (GSC) as an overarching framework that could act as a single entry point for all their minimum information checklists (as reported in Nature Biotechnology).

MIxS includes the technology-specific checklists from the previous MIGS and MIMS standards (for genomes and metagenomes respectively), provides a way of introducing additional checklists such as MIMARKS (for marker sequences), and also allows annotation of sample data using environmental packages.

A specification of how to embed OME-XML metadata within a TIFF or BigTIFF image file.

OME-XML is a vendor-neutral file format for biological image data, with an emphasis on metadata supporting light microscopy. It can be used as a data file format in its own right, or as a way of encoding metadata within a TIFF or BigTIFF file (for which purpose there is the OME-TIFF specification).

The standard is maintained by the Open Microscopy Environment Consortium, and was last updated in June 2012.

Recommended Metadata for Biological Images (REMBI) provides guidelines for metadata for biological images to enable the FAIR sharing of scientific data. REMBI is the result of the bioimaging community coming together to develop metadata standards that describe the imaging data itself, together with supporting metadata such as those describing the biological study and sample.

An ISA-Tab-based standard for reporting the results of single nucleotide resolution nucleic acid structure mapping experiments.